February 25, 2017

BARCHAN: Blob Alignment for Robust CHromatographic ANalysis

Journal of Chromatography A

By: Camille Couprie, Laurent Duval, Maxime Moreaud, Melinda Tebib, Sophie Henon, Vincent Souchon

Abstract

Two dimensional gas chromatography (GC×GC) plays a central role into the elucidation of complex samples. The automation of the identification of peak areas is of prime interest to obtain a fast and repeatable analysis of chromatograms. To determine the concentration of compounds or pseudo-compounds, templates of blobs are defined and superimposed on a reference chromatogram. The templates then need to be modified when different chromatograms are recorded. In this study, we present a chromatogram and template alignment method based on peak registration called BARCHAN.